11 Marzo 2022. Seminari fra Giovani Ricercatori: Multiscale modeling of restenosis after endovascular intervention in femoral arteries
Seminari fra Giovani Ricercatori.
“Multiscale modeling of restenosis after endovascular intervention in femoral arteries”
Anna Corti (PhD Student @ Laboratory of Biological Structure Mechanics (LaBS), Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano)
Claudio Chiastra (Associate professor @ PoliToBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino)
“Restenosis is an inflammatory-driven response of superficial femoral arteries to percutaneous transluminal angioplasty with/without stent placement, characterized by exacerbated cellular proliferative and synthetic activities, leading to lumen re-narrowing and failure of the procedure. Although multiple systemic, biological and biomechanical drivers are known to promote restenosis, a thorough understanding of its underlying mechanisms is lacking. In this context, multiscale mechanobiological modeling relating the intervention-induced mechanical stimuli to the complex network of biological events has recently emerged as a fundamental approach to decipher the underlying pathological pathways. This seminar will focus on the multiscale modeling of restenosis in femoral arteries, based on the integration of continuum and agent-based approaches. Both idealized and patient-specific multiscale agent-based modelling frameworks of restenosis, developed within the project TIME (from TIssue to Molecular mechanisms of restenosis after peripheral Endovascular interventions, https://timesfa.wixsite.com/time, funded by Fondazione Cariplo), will be illustrated.